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4-ACO-DMT, O-Acetylpsilocin is a synthetically generated psychedelic medication and has been recommended by David Nichols to be a potentially helpful alternative to psilocybin for medicinal studies, as they are both believed to be prodrugs of psilocin.
4-ACO-DMT (also referred to as O-Acetylpsilocin, 4-Acetoxy-DMT, or Psilacetin) is a synthetically generated psychedelic tryptamine. It is the acetylated form of the psilocybin mushroom alkaloid psilocin and is a lower homolog of 4-AcO-DET, 4-AcO-MiPT, and 4-AcO-DiPT. David Nichols has suggested the compound as a potentially valuable option to psilocybin for pharmacological research studies as they are both thought to be prodrugs of psilocin. [1] Its structural resemblances to psilocin and psilocybin result in a similar subjective result account, and the three compounds can be claimed to feel identical. This allows 4-AcO-DMT to work as an excellent alternative to psilocybin mushrooms.
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44-ACO-DMT and several other esters of psilocin were originally patented on January 16, 1963, by Sandoz Ltd. via Albert Hofmann & Franz Troxler. [2] [3] Despite this reality, 4-AcO-DMT remains a psychedelic with a minimal history of use before its launch as a grey-location substance on the online research chemical market.
4-ACO-DMT’s psychedelic effects are thought to be found from its efficiency at the 5-HT2A receptor as a partial agonist. Nevertheless, the function of these interactions and how they result in the psychedelic experience remains elusive.
In the body, 4-AcO-DMT/psilocin is thought to be deacetylated into psilocin throughout the first pass metabolism and succeeding go through the liver (apparent as psilocybin is additionally active when injected). However, this has not been formally verified and is based on records that many users can not distinguish between these two substances when consumed to the point that they are commonly thought about as equivalent to each other regarding their subjective results.
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There are, nonetheless, insurance claims of subjective differences in effect between the acetylated and non-acetylated types of psilocin. [4] Some users report that it lasts slightly longer than psilocin, while others say that it lasts for a substantially shorter time. Many users report less body load and nausea compared to psilocin. Some customers find that the aesthetic distortions generated by 4-AcO-DMT much more closely resemble those produced by DMT than those caused by psilocin. These distinctions could be possible if 4-AcO-DMT is active itself and not merely as a prodrug.
