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In the body, 4-AcO-DMT / psilacetin is thought to be deacetylated into psilocin during first pass metabolism and subsequent passes through the liver (evident as psilacetin is also active when injected). This has not been formally proven, however, and is based on reports that most users cannot tell the difference between these two compounds when ingested to the point that they are often considered as indistinguishable from each other in terms of their subjective effects.
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However, When smoked, the average dose of DMT is 30-150 mg, and the onset of action can be felt almost instantly. The effects peak and plateau for 3-5 minutes and gradually drop off with the duration of effect totaling 30-45 minutes.
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MDMA stands for the chiral chemical compound 3,4-methylenedioxy-N-methylamphetamine. Structurally, it belongs to the group of methylenedioxyamphetamines and is known in particular as a worldwide party drug.
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